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1995年创刊，中华人民共和国卫生部主管，中华医学会、国际医药卫生导报社主办。本刊是综合性医学学术期刊，主要栏目：科研课题、基础研究、专家述评、临床研究、病例报告、药物与临床、药学研究、临床检验、中医中药、预防医学、护理研究、医学动态等。
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首页>国际医药卫生导报杂志
- 杂志名称：国际医药卫生导报杂志
- 主管单位：中华人民共和国卫生和计划生育委员会
- 主办单位：中华医学会;国际医药卫生导报社
- 国际刊号：1007-1245
- 国内刊号：44-1417/R
- 出版周期：半月刊
期刊荣誉：中国期刊全文数据库(CJFD)期刊收录：国家图书馆馆藏, 上海图书馆馆藏, 知网收录(中), 维普收录(中), 万方收录(中)
Relationship between the level of NT-proBNP and left ventricular diastolic function in chronic heart failure patients with preserved ejection fraction
Zhu Youfeng；Li Kong；Wei Jianrui；Yin Haiyan；Zhang Rui
关键词：Echocardiography, Heart failure with preserved ejection fraction, Tissue Doppler, N-terminal pro-brain natriuretic peptide
摘要：Objective To investigate the relationship between n-terminal pro-brain natriuretic peptide (NT-proBNP) level and echocardiographic parameter in patients with chronic heart failure with preserved ejection fraction (HFPEF) and evaluate the correlation,specificity and sensitivity on these indices.Methods Sixty-six symptomatic patients with isolated diastolic dysfunction and preserved left ventricular ejection fraction (LVEF) (≥ 50％) and forty-three people with normal left ventricular (LV) function were examined by conventional echocardiography,tissue Doppler imaging (TDI).Plasma NT-proBNP levels were determined simultaneously.Results Compared with control group,NT-proBNP,E/Em,LVMI were significantly higher in HFPEF (P ＜ 0.01); NT-proBNP was significantly correlated with E/Em (correlation coefficient r =0.576).Conclusion NT-proBNP,E/Em,LVMI were significant markers for reflecting left ventricular diastolic function and good tools for diagnosing HFPEF.NT-proBNP had a significant negative predictive value (92.7％) when NT-proBNP ＜ 90 pg/ml.
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